BMVC-8C3O

Chemical Structure : BMVC-8C3O

CAS No.: 1301708-12-2

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货号: PC-24467Not For Human Use, Lab Use Only.

BMVC-8C3O is a novel small molecule inhibitor of Mycobacterium tuberculosis Pks13 with IC50 of 6.94 uM and SPR KD of 18.9 uM, also is a small molecule G-quadruplex (G4) ligand.

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10 mg	￥5480	In stock
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生物&药学活性

BMVC-8C3O is a novel small molecule inhibitor of Mycobacterium tuberculosis Pks13 with IC50 of 6.94 uM and SPR KD of 18.9 uM, also is a small molecule G-quadruplex (G4) ligand.
BMVC-8C3O displays potential intracellular anti-TB activity in macrophages.
BMVC-8C3O also is a DNA G4 ligand, is effective for non-small cell lung cancer.
BMVC-8C3O effectively suppresses c-FOS expression by stabilizing G-rich sequences located at the c-FOS promoter.
BMVC-8C3O exhibits inhibitory effects against H37Rv and STB-30308, with MICs of 8.291 as well as 5.492 μg/mL separately.

物理化学性质&存储条件

分子量	1042.61
分子式	C42H53N4O3.3I
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyridinium, 4,4′-[[9-[2-[2-[2-[2-(1-methylpiperidinio)ethoxy]ethoxy]ethoxy]ethyl]-9H-carbazole-3,6-diyl]di-2,1-ethenediyl]bis[1-methyl-, iodide (1:3)

参考文献

1. Lu K, et al. J Natl Cancer Inst. 2023 Nov 8;115(11):1383-1391.

2. Wang ZF, et al. Nucleic Acids Res. 2016 May 5;44(8):3958-68.

3. Liu T, et al. Tuberculosis (Edinb). 2025 Jan;150:102579.

BMVC-8C3O

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BMVC-8C3O

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