BMS493 (BMS-204493) | pan-RAR inverse agonist, TLX agonist

Chemical Structure : BMS493

CAS No.: 215030-90-3

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BMS493 (BMS-204493, BMS204493)

货号: PC-70293Not For Human Use, Lab Use Only.

BMS493 (BMS-204493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM, also is an agonist of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 54 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

BMS493 (BMS-204493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM, also is an agonist of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 54 nM.
BMS-204493 (BMS493) prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.
BMS-204493 (BMS493) blocks the ATRA-induced vasorelaxation.

物理化学性质&存储条件

分子量	404.5
分子式	C29H24O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]benzoic acid

参考文献

1. García-Rodríguez J, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1285-302.

2. Das BC, et al. Tetrahedron Lett. 2012 Mar 14;53(11):1316-1318.

3. Wang Y, et al. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H51-7.

BMS493 (BMS-204493, BMS204493)

生物&药学活性

物理化学性质&存储条件

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BMS493 (BMS-204493, BMS204493)

生物&药学活性

物理化学性质&存储条件

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