BMS-P5 | PAD4 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-P5

CAS No.: 1550371-22-6

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BMS-P5 (PAD4 inhibitor BMS-P5)

货号: PC-38089Not For Human Use, Lab Use Only.

BMS-P5 is a potent, specific inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 98 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

BMS-P5 is a potent, specific inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 98 nM.
BMS-P5 is selective for PAD4 over PAD1, -2, and -3 (IC50s >10 uM).
BMS-P5 inhibits PAD4 and prevents mouse myeloma-induced NET formation, prevents NETosis induced by human myeloma cells.
BMS-P5 significantly reduces plasma levels of cell-free DNA, exhibits anti-tumor effect in a syngeneic mouse model of multiple myeloma.

物理化学性质&存储条件

分子量	472.593
分子式	C27H32N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,5R)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone

参考文献

1. Marina Li, et al. Mol Cancer Ther. 2020 Jul;19(7):1530-1538.

BMS-P5 (PAD4 inhibitor BMS-P5)

生物&药学活性

物理化学性质&存储条件

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BMS-P5 (PAD4 inhibitor BMS-P5)

生物&药学活性

物理化学性质&存储条件

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