BMS-986449 | IKZF2/4 degrader | Probechem Biochemicals

Chemical Structure : BMS-986449

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BMS-986449 (BMS986449)

货号: PC-24664Not For Human Use, Lab Use Only.

BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4).

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4).
BMS-986449 shows minimal impact on IKZF1/3 levels in regulatory T-cells as assessed by global proteomics.
BMS-986449 affects in vitro reprogramming of Treg cells to have a more effector-like phenotype that results in promising in vivo efficacy in syngeneic tumor models.

物理化学性质&存储条件

分子量	395.43
分子式	C22H22FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((2R,3S)-5-(6-amino-4,5-dimethylpyridin-2-yl)-4-fluoro-3-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)piperidine-2,6-dione

参考文献

1. Aaron Balog. Cancer Res (2025) 85 (8_Supplement_2): ND05.

BMS-986449 (BMS986449)

生物&药学活性

物理化学性质&存储条件

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BMS-986449 (BMS986449)

生物&药学活性

物理化学性质&存储条件

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