BMS-986331 | FPR2 agonist | Probechem Biochemicals

Chemical Structure : BMS-986331

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BMS-986331 (BMS986331)

货号: PC-26270Not For Human Use, Lab Use Only.

BMS-986331 is a highly potent and selective Formyl peptide receptor 2 (FPR2) agonist with EC50 of 0.5 nM (hFPR2).

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生物&药学活性

BMS-986331 is a highly potent and selective Formyl peptide receptor 2 (FPR2) agonist with EC50 of 0.5 nM (hFPR2).
BMS-986331 exhibits rat FPR2 cAMP EC50 of 1 nM, 220-fold selective over rFPR1.
BMS-986331 induces concentration-dependent modulation of bioluminescence resonance energy transfer (BRET) signals for Gαi2 (EC50=0.5 nM), GαoA (EC50=0.5 nM), Gα12 (EC50=16 nM), and Gα13 (EC50=13 nM) biosensors following FPR2 activation in in HEK293 cells transiently expressing human FPR2.
BMS-986331 exhibits excellent activity in inducing the expression and release of the pro-resolution cytokine IL-10 in isolated human whole blood and in an acute rat model of systemic inflammation, respectively.
BMS-986331 (0.1, 1, or 10 mg/kg/day, PEG 400/PG/TPGS/water, 40:10:10:40) preserves myocardial structure and improves cardiac function in the rat MI model.

物理化学性质&存储条件

分子量	535.89
分子式	C25H22ClF3N3O3P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(4-Chloro-2-fluorophenyl)-3-(1-(2′-(dimethylphosphoryl)-2,3-difluoro-[1,1′-biphenyl]-4-yl)-2-oxopyrrolidin-3-yl)urea

参考文献

1. Shirude PS, et al. J Med Chem. 2026 Feb 26;69(4):4078-4089.

BMS-986331 (BMS986331)

生物&药学活性

物理化学性质&存储条件

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BMS-986331 (BMS986331)

生物&药学活性

物理化学性质&存储条件

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