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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-BMS-986318
BMS-986318

Chemical Structure : BMS-986318

CAS No.: 2314378-09-9

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BMS-986318 (BMS986318)

货号: PC-20976Not For Human Use, Lab Use Only.

BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.
    BMS-986318 exhibits EC50 of 350 nM in FXR steroid receptor coactivator 1 (SRC-1) recruitment assays.
    BMS-986318 (10, 30, and 100 mg/kg) demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.

    物理化学性质&存储条件

    分子量 615.43
    分子式 C30H23Cl2F3N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid

    参考文献

    1. Carpenter J, et al. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420.

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