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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-BMS-986187
BMS-986187

Chemical Structure : BMS-986187

CAS No.: 684238-37-7

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BMS-986187 (BMS986187)

货号: PC-63082Not For Human Use, Lab Use Only.

BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor (DOR) with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor.

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor (DOR) with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor.

物理化学性质&存储条件

分子量 470.609
分子式 C31H34O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione

参考文献

1. Livingston KE, et al. Mol Pharmacol. 2018 Feb;93(2):157-167.

2. Shang Y, et al. ACS Chem Biol. 2016 May 20;11(5):1220-9.

3. Burford NT, et al. J Med Chem. 2015 May 28;58(10):4220-9.

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