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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-BMS-905
BMS-905

Chemical Structure : BMS-905

CAS No.: 2205846-49-5

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BMS-905 (BMS905)

货号: PC-38500Not For Human Use, Lab Use Only.

BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members.

物理化学性质&存储条件

分子量 347.506
分子式 C23H29N3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole

参考文献

1. Ratna Kumar Sreekantha, et al. ACS Medicinal Chemistry Letters. DOI: 10.1021/acsmedchemlett.2c00049

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