BMS-814580 phosphate | MCHR1 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-814580 phosphate

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BMS-814580 phosphate (BMS814580 phosphate)

货号: PC-61119Not For Human Use, Lab Use Only.

BMS-814580 phosphate is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.

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生物&药学活性

BMS-814580 phosphate is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
BMS-814580 phosphate exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM.
BMS-814580 phosphate dose-dependently reduces body weight in chronic diet-induced obese models with excellent safety profile.

物理化学性质&存储条件

分子量	584.912
分子式	C24H20ClF2N2O7PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one phosphate

参考文献

1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858.

BMS-814580 phosphate (BMS814580 phosphate)

生物&药学活性

物理化学性质&存储条件

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BMS-814580 phosphate (BMS814580 phosphate)

生物&药学活性

物理化学性质&存储条件

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