BMS-262084 | Tryptase inhibitor, FXIa inhibitor | Probechem Biochemicals

Chemical Structure : BMS-262084

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BMS-262084 (BMS262084)

货号: PC-25174Not For Human Use, Lab Use Only.

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor Xia with IC50 of 2.8 nM, shows antithrombotic effects.

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生物&药学活性

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor XIa with IC50 of 2.8 nM, shows antithrombotic effects.

物理化学性质&存储条件

分子量	425.49
分子式	C18H31N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-1-(4-(tert-butylcarbamoyl)piperazine-1-carbonyl)-3-(3-((diaminomethylene)amino)propyl)-4-oxoazetidine-2-carboxylic acid

参考文献

1. Slusarchyk WA, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8.

2. Schumacher WA, et al. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74.

BMS-262084 (BMS262084)

生物&药学活性

物理化学性质&存储条件

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BMS-262084 (BMS262084)

生物&药学活性

物理化学性质&存储条件

参考文献

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