BMS-204352 |CAS:187523-35-9 Probechem Biochemicals

Chemical Structure : BMS-204352

CAS No.: 187523-35-9

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BMS-204352 (Flindokalner, BMS 204352, Maxipost)

货号: PC-60688Not For Human Use, Lab Use Only.

Flindokalner (BMS-204352) is a potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

Flindokalner (BMS-204352) is a potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
Flindokalner (BMS-204352) is a potent and effective opener of two important subtypes of neuronal potassium channels, K(Ca) channels and KCNQ channels, strongly activates the voltage-gated K+ channel KCNQ5 with EC50 of 2.4 uM.
Flindokalner (BMS-204352)shows significant levels of cortical neuroprotection in rat models of permanent large-vessel stroke.

物理化学性质&存储条件

分子量	359.7
分子式	C16H10ClF4NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one

参考文献

1. Gribkoff VK, et al. Nat Med. 2001 Apr;7(4):471-7.

2. Schrøder RL, et al. Neuropharmacology. 2001 Jun;40(7):888-98.

3. Dupuis DS, et al. Eur J Pharmacol. 2002 Feb 22;437(3):129-37.

4. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1023-6.

BMS-204352 (Flindokalner, BMS 204352, Maxipost)

生物&药学活性

物理化学性质&存储条件

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BMS-204352 (Flindokalner, BMS 204352, Maxipost)

生物&药学活性

物理化学性质&存储条件

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