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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-BMS-195614
BMS-195614

Chemical Structure : BMS-195614

CAS No.: 182135-66-6

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BMS-195614 (BMS 614, BMS195614)

货号: PC-20198Not For Human Use, Lab Use Only.

BMS-195614 (BMS614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-195614 (BMS614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM.
BMS-195614 (BMS614) antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding.

物理化学性质&存储条件

分子量 448.52
分子式 C29H24N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxamido)benzoic acid

参考文献

1. M Géhin, et al. Chem Biol. 1999 Aug;6(8):519-29.

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