BMS-193885 | Y1R antagonist | Probechem Biochemicals

Chemical Structure : BMS-193885

CAS No.: 186185-03-5

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BMS-193885 (BMS193885)

货号: PC-26144Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

BMS-193885 is a potent, selective neuropeptide Y(1) receptor (Y1R) antagonist with binding Ki of 3.3 nM, demonstrates full functional antagonism with Kb of 4.54 nM in forskolin-stimulated c-AMP production assay using CHO cells expressing human Y(1) receptor.
BMS-193885 inhibited NPY-induced feeding in satiated rats when dosed at 3.0 and 10.0 mg/kg (ip), and also decreased spontaneous overnight food consumption in rats at doses of 10 and 20 mg/kg (ip).
BMS-193885 (10 mg/kg) also reduced one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption.

物理化学性质&存储条件

分子量	590.72
分子式	C33H42N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl 4-(3-(3-(3-(4-(3-methoxyphenyl)piperidin-1-yl)propyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

参考文献

1. Antal-Zimanyi I, et al. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.

2. Poindexter GS, et al. Bioorg Med Chem. 2004 Jan 15;12(2):507-21.

BMS-193885 (BMS193885)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-193885 (BMS193885)

生物&药学活性

物理化学性质&存储条件

参考文献

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