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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-BMS-159
BMS-159

Chemical Structure : BMS-159

CAS No.: 1541248-45-6

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BMS-159 (BMS159)

货号: PC-26004Not For Human Use, Lab Use Only.

BMS-159 is the orally bioavailabile phosphate prodrug of BMS-135, which is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMS-159 is the orally bioavailabile phosphate prodrug of BMS-135, which is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.

物理化学性质&存储条件

分子量 590.92
分子式 C22H24ClN10O6P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl ((3R,4R)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-(phosphonooxy)piperidin-4-yl)carbamate

参考文献

1. A M Subbaiah M, et al. J Med Chem. 2026 Jan 22;69(2):1641-1660.

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