BMS-135 | CK2 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-135

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BMS-135 (BMS135)

货号: PC-26003Not For Human Use, Lab Use Only.

BMS-135 is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.

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生物&药学活性

BMS-135 is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.
BMS-135 demonstrated robust antiproliferative activity, with an IC50 of 8 nM in SNU-C1 colon cancer cells.
BMS-135 (15 mg/kg, twice daily) demonstrated marked antitumor efficacy in SNU-C1 colon carcinoma xenograft model.
BMS-135 also demonstrated broad-spectrum antitumor efficacy across multiple lung cancer xenograft and patient-derived xenograft (PDX) models.

物理化学性质&存储条件

分子量	510.94
分子式	C22H23ClN10O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl ((3R,4R)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-hydroxypiperidin-4-yl)carbamate

参考文献

1. A M Subbaiah M, et al. J Med Chem. 2026 Jan 22;69(2):1641-1660.

BMS-135 (BMS135)

生物&药学活性

物理化学性质&存储条件

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BMS-135 (BMS135)

生物&药学活性

物理化学性质&存储条件

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