BLU3797 | PIK3C2B inhibitor | Probechem Biochemicals

Chemical Structure : BLU3797

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BLU3797 (BLU-3797)

货号: PC-26519Not For Human Use, Lab Use Only.

BLU3797 is a highly potent, selective, orally bioavailable PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase) inhibitor with IC50 of 28 nM (1 mM ATP), while sparing other PI3K family members.

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生物&药学活性

BLU3797 is a highly potent, selective, orally bioavailable PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase) inhibitor with IC50 of 28 nM (1 mM ATP), while sparing other PI3K family members.
BLU3797 has low affinity for other kinases in general as assessed by kinome scan, with an overall S(10) selectivity score of 0.015.
BLU3797 (3 uM) promotes myocyte-myotube fusion in C2C12 cells.
BLU3797 effectively rescues the MTM1-null phenotype
BLU3797 normalizes disease biomarkers, improves muscle function, and enhances survival in preclinical models of X-linked myotubular myopathy (XLMTM).

物理化学性质&存储条件

分子量	425.55
分子式	C23H27N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-(2-(1-cyclopropylethyl)-7-(cyclopropylmethoxy)-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)acetamide

参考文献

1. Shearer A, et al. JCI Insight. 2026 Apr 9:e198568.

BLU3797 (BLU-3797)

生物&药学活性

物理化学性质&存储条件

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BLU3797 (BLU-3797)

生物&药学活性

物理化学性质&存储条件

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