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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-BKI-1841
BKI-1841

Chemical Structure : BKI-1841

CAS No.:

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BKI-1841 (BKI 1841)

货号: PC-25202Not For Human Use, Lab Use Only.

BKI-1841 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 3 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.7 uM against C. parvum parasites in Nanoluciferase assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BKI-1841 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 3 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.7 uM against C. parvum parasites in Nanoluciferase assays.

物理化学性质&存储条件

分子量 381.44
分子式 C20H23N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-amino-3-(2-ethoxyquinolin-6-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide

参考文献

1. Hulverson MA, et al. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0142522.

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