BK50118-C | USP13 inhibitor | Probechem Biochemicals

Chemical Structure : BK50118-C

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BK50118-C (BK 50118-C)

货号: PC-20796Not For Human Use, Lab Use Only.

BK50118-C is a potent small molecule inhibitor of ubiquitin-specific protease-13 (USP13) with IC50 of 0.42 nM.

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生物&药学活性

BK50118-C is a potent small molecule inhibitor of ubiquitin-specific protease-13 (USP13) with IC50 of 0.42 nM.
BK50118-C potently decreased alpha-synuclein levels, reaching almost complete alpha-synuclein clearance at 1 mM and 100 µM via measurement of human alpha-synuclein via ELISA.
BK50118-C (daily dosage of 10 mg/Kg or 40 mg/Kg for 7 days) significantly reduced alpha-synuclein but not p-tau levels in TgA53T mice, reduced the number of human alpha-synuclein positive neurons by 42% in cortex and 40% in striatum.
BK50118-C significantly increased alpha-synuclein ubiquitination but had minimal effects on tyrosine hydroxylase (TH) levels in striatum of TgA53T mice.
BK50118-C (100 mg/kg) significantly reduced ubiquitinated alpha-synuclein, increased dopamine levels, and improved motor and behavioral symptoms in wild-type (USP13+/+), but not USP13 deficient, mice.

物理化学性质&存储条件

分子量	253.28
分子式	C16H12FNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(benzyloxy)-6-fluoroquinoline

参考文献

1. Xiaoguang Liu, et al. Metabolites. 2021 Sep 15;11(9):622.

BK50118-C (BK 50118-C)

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BK50118-C (BK 50118-C)

生物&药学活性

物理化学性质&存储条件

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