BJE6-106 |CAS:1564249-38-2 Probechem Biochemicals

Chemical Structure : BJE6-106

CAS No.: 1564249-38-2

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BJE6-106 (B106)

货号: PC-62375Not For Human Use, Lab Use Only.

BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα).

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5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα).
BJE6-106 induces cell growth inhibition in melanoma cell lines with NRAS mutations at nanomolar concentrations.
BJE6-106 induces phosphorylation (activation) of JNK1/2 (T183/Y185) most strongly after two hr of exposure in SBcl2 cells, induces phosphorylation of MKK4, JNK and H2AX in NRAS mutant melanoma WM1366 cells.

物理化学性质&存储条件

分子量	381.475
分子式	C26H23NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-(9H-carbazol-9-yl)ethyl)-2,2-dimethyl-2H-chromene-8-carbaldehyde

参考文献

1. Takashima A, et al. ACS Chem Biol. 2014 Apr 18;9(4):1003-14.

BJE6-106 (B106)

生物&药学活性

物理化学性质&存储条件

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BJE6-106 (B106)

生物&药学活性

物理化学性质&存储条件

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