BJ-2412 | RYK inhibitor | Probechem Biochemicals

Chemical Structure : BJ-2412

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BJ-2412 (BJ2412)

货号: PC-27975Not For Human Use, Lab Use Only.

BJ-2412 is a small molecule inhibitor of receptor-like tyrosine kinase RYK, inhibits RYK phosphorylation by disrupting its interaction with EGFR, shows anticancer activity against PDAC.

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生物&药学活性

BJ-2412 is a small molecule inhibitor of receptor-like tyrosine kinase RYK, inhibits RYK phosphorylation by disrupting its interaction with EGFR, shows anticancer activity against PDAC.
BJ-2412 inactivated GSK-3β and reduced Sonic Hedgehog (Shh) and GLI1 expression.
BJ-2412 impaired cancer cell survival, including that of cancer stem cells, had minimal effects on proliferation
BJ-2412-induced up-regulation of WNT5A, cancer cell-selective apoptosis, M1-macrophage polarization, as well as down-regulation of MMPs and CTSS.
BJ-2412 suppressed tumour growth, invasion, and metastasis in xenograft and allograft mouse models.

物理化学性质&存储条件

分子量	425.53
分子式	C23H31N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(2-(diethylamino)ethyl)-5-((5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-pyrrolo[2,3-b]pyridin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

参考文献

1. Kiran Yadav, et al. Br J Pharmacol. 2026 Aug;183(15):4196-4214.

BJ-2412 (BJ2412)

生物&药学活性

物理化学性质&存储条件

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BJ-2412 (BJ2412)

生物&药学活性

物理化学性质&存储条件

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