欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-BIO-8169
BIO-8169

Chemical Structure : BIO-8169

CAS No.: 2792153-06-9

加入收藏

BIO-8169 (BIO 8169)

货号: PC-22268Not For Human Use, Lab Use Only.

BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays.
    BIO-8169 displays high selectivity in a broad kinome panel (Eurofins: 468 kinases) at 1 uM, only three kinases in the panel shows greater than 80% inhibition (FLT3: 418 nM, TRKA: 752 nM, TRKB: 1155 nM).
    BIO-8169 has an excellent PK profile, reduces the in vivo production of pro-inflammatory cytokines, and is tolerated in toxicity studies in rodents and dogs at margins.
    BIO-8169 (30 mg/kg QD and 20 mg/kg BID) inhibited the development of EAE with concomitant reduction of number of inflammatory foci, T cell infiltrates, and activated microglial and macrophage density, in mouse model of human multiple sclerosis.

    物理化学性质&存储条件

    分子量 449.51
    分子式 C24H27N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-cyclopropyl-2-oxo-1,2-dihydropyridin-3-yl)-7-isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)imidazo[1,2-a]pyrimidine-6-carboxamide

    参考文献

    1. Pfaffenbach M, et al. J Med Chem. 2024 May 2. doi: 10.1021/acs.jmedchem.4c00560.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: