BIBP3226 TFA

Chemical Structure : BIBP3226 TFA

CAS No.: 1068148-47-9

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货号: PC-27939Not For Human Use, Lab Use Only.

BIBP3226 TFA (BIBP 3226) is a highly potent and selective non-peptide neuropeptide Y Y1 receptor (NPY1R) antagonist with Ki of 7 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BIBP3226 TFA (BIBP 3226) is a highly potent and selective non-peptide neuropeptide Y Y1 receptor (NPY1R) antagonist with Ki of 7 nM.
BIBP3226 potently blocks (pA2 = 7.36) the contractile effect of neuropeptide Y in the rabbit saphenous vein, a Y1 receptor bioassay and demonstrated nM affinity for Y1/[125I][Leu31,Pro34]peptide YY binding sites.
BIBP3226 (BIBP 3226) does not significantly compete for Y2/[125I]peptide YY-(3-36) binding sites in rat and human brain homogenates.
BIBP3226 (BIBP 3226) antagonizes the NPY Y1 receptor-mediated decrease in the twitch response in the rabbit vas deferens preparation with a pKb value of 6.98.
BIBP3226 (BIBP 3226) inhibits NPY-induced increase in blood pressure in the pithed rat.

物理化学性质&存储条件

分子量	587.60
分子式	C29H32F3N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide 2,2,2-trifluoroacetate

参考文献

1. Jacques D, et al. Eur J Pharmacol. 1995 May 4;278(1):R3-5.

2. Rudolf K, et al. Eur J Pharmacol. 1994 Dec 27;271(2-3):R11-3.

3. Mollereau C, et al. Br J Pharmacol. 2001 May;133(1):1-4.

BIBP3226 TFA

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BIBP3226 TFA

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