BI 831266 | AURKB inhibitor | Probechem Biochemicals

Chemical Structure : BI 831266

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BI 831266 (BI831266)

货号: PC-63253Not For Human Use, Lab Use Only.

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.

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生物&药学活性

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
BI 831266 inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM).
BI 831266 causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC).

物理化学性质&存储条件

分子量	528.098
分子式	C27H38ClN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5-chloro-4-(((1R,2S)-2-(isopropylcarbamoyl)cyclopentyl)amino)pyrimidin-2-yl)amino)-N-methyl-N-(1-methylpiperidin-4-yl)benzamide

参考文献

1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22.

BI 831266 (BI831266)

生物&药学活性

物理化学性质&存储条件

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BI 831266 (BI831266)

生物&药学活性

物理化学性质&存储条件

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