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首页-小分子抑制剂&激动剂-Others-Other Targets-BI033
BI033

Chemical Structure : BI033

CAS No.: 880810-80-0

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BI033 (BI-033)

货号: PC-25146Not For Human Use, Lab Use Only.

BI033 is a selective small-molecule BTB and CNC homology 1 (BACH1) inhibitor, specifically binds to BACH1 WT with Kd of 9.0 uM, significantly upregulates HO-1 mRNA and protein expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BI033 is a selective small-molecule BTB and CNC homology 1 (BACH1) inhibitor, specifically binds to BACH1 WT with Kd of 9.0 uM, significantly upregulates HO-1 mRNA and protein expression.
BI033 specifically interacts with the N-terminal alanine residue at position 91 within the BTB domain of the BACH1 protein, could not bind to BACH1 91W.
BI033 (1 uM) exhibited a significant increase in HO-1 transcriptional activity in the BACH1 WT overexpressing cells but had a less pronounced effect on HO-1 transcriptional activity in the BACH1 91W overexpressing cells.
BI033 (1 uM) increased VEGFA expression in a time-dependent manner, exhibits greater angiogenic ability on endothelial cells (ECs) than HPPE.
BI033 treatment (1 and 5 mg/kg, i.p.) promotes angiogenesis in the infarcted heart of mice, enhances blood perfusion and angiogenesis in the ischemic hindlimb murine model.
BI033 promotes the expression of proangiogenic genes such as HMOX1 (HO-1), VEGFA, cyclin D1 (CCND1), and activating transcription factor 3 (ATF3) and suppresses inflammatory responses in HUVECs.
BI033 reduces BACH1 nuclear localization and HDAC1 occupancy on BACH1 target genes.

物理化学性质&存储条件

分子量 384.90
分子式 C22H25ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((2-(((2-((4-chlorobenzyl)oxy)naphthalen-1-yl)methyl)amino)ethyl)amino)ethan-1-ol

参考文献

1. Lin J, et al. Mol Ther. 2025 Jul 16:S1525-0016(25)00544-1.

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