BI-8925 | MLKL inhibitor | Probechem Biochemicals

Chemical Structure : BI-8925

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BI-8925 (BI 8925)

货号: PC-24410Not For Human Use, Lab Use Only.

BI-8925 is a potent, selective and covalent inhibitor of mixed lineage kinase domain-like (MLKL), inhibits necroptosis in Jurkat and U937 cells with an IC50 of 541 and 271 nM, respectively.

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生物&药学活性

BI-8925 is a potent, selective and covalent inhibitor of mixed lineage kinase domain-like (MLKL), inhibits necroptosis in Jurkat and U937 cells with an IC50 of 541 and 271 nM, respectively.

物理化学性质&存储条件

分子量	346.36
分子式	C12H18N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((2-methoxyethoxy)methyl)-1,3-dimethyl-8-(methylsulfonyl)-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Martin Rübbelke, et al. J Med Chem. 2021 Nov 11;64(21):15629-15638.

BI-8925 (BI 8925)

生物&药学活性

物理化学性质&存储条件

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BI-8925 (BI 8925)

生物&药学活性

物理化学性质&存储条件

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