BI-847325 |CAS:1207293-36-4 Probechem Biochemicals

Chemical Structure : BI-847325

CAS No.: 1207293-36-4

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BI-847325 (BI847325;BI 847325)

货号: PC-45572Not For Human Use, Lab Use Only.

BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM).

规格	价格	库存
10 mg	￥1680	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM).
BI-847325 also inhibits MEK1 (IC50=25 nM) and MEK2 (IC50=6 nM).
BI-847325 reduces expression of p-ERK and p-Histone 3 in multiple models of vemurafenib resistance.
BI-847325 decreases the expression of MEK and Mcl-1 and increases the expression of BIM.
BI-847325 is orally bioavailable.

物理化学性质&存储条件

分子量	464.5582
分子式	C29H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥36 mg/mL
Chemical Name/SMILES	2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-

参考文献

1. Phadke MS, et al. Mol Cancer Ther. 2015 Jun;14(6):1354-64.

2. Sini P, et al. Mol Cancer Ther. 2016 Oct;15(10):2388-2398.

BI-847325 (BI847325;BI 847325)

生物&药学活性

物理化学性质&存储条件

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BI-847325 (BI847325;BI 847325)

生物&药学活性

物理化学性质&存储条件

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