欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-BI-5756
BI-5756

Chemical Structure : BI-5756

CAS No.: 1332485-18-3

加入收藏

BI-5756 (BI 5756)

货号: PC-25525Not For Human Use, Lab Use Only.

BI-5756 is a cholesteryl ester transfer protein (CETP) inhibitor, also is a potent agonist of cannabinoid receptor 1 (CB1R, CB1) with IC50 of 0.966 uM in cell-based radioligand binding assay using CP55940.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BI-5756 is a cholesteryl ester transfer protein (CETP) inhibitor, also is a potent agonist of cannabinoid receptor 1 (CB1R, CB1) with IC50 of 0.966 uM in cell-based radioligand binding assay using CP55940.
BI-5756 directly increases the frequencies of regulatory T cells (Tregs) in primary murine pan T cells after activation.
BI-5756 exhibits an in vivo protective effect against graft-versus-host disease (GvHD), an allogeneic T cell-mediated inflammatory complication after allogeneic hematopoietic cell transplantation (allo-HCT), resulting in an improved overall survival with enhanced platelet recovery and reconstitution of bone marrow-derived B and T cells.
BI-5756 also directly suppresses tumor cell growth and upregulates MHC I, MHC II, and CD80 on tumor cells, which may subsequently BI-5756 enhance T cell-mediated anti-tumor responses in mixed lymphocyte reaction with A20 cells.
BI-5756 exhibits immunomodulatory effect which is mediated via CB1.
BI-5756 shows a robust elevation of HDL-C and reduction of LDL-C.

物理化学性质&存储条件

分子量 475.55
分子式 C27H32F3NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,9S)-4-isopropyl-7,7-dimethyl-3-(4-(trifluoromethyl)phenyl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]-9-ol

参考文献

1. Sena Kim, et al. Molecules. 2025 Aug 28;30(17):3517.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: