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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-BI-167107
BI-167107

Chemical Structure : BI-167107

CAS No.: 1202235-68-4

BI-167107 (BI 167107, BI 167107)

货号: PC-35028Not For Human Use, Lab Use Only.

BI-167107 (BI 167107) is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

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10 mg ¥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI-167107 (BI 167107) is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

物理化学性质&存储条件

分子量 370.449
分子式 C21H26N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-hydroxy-8-(1-hydroxy-2-((2-methyl-1-(o-tolyl)propan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

参考文献

1. Weiss DR, et al. ACS Chem Biol. 2013 May 17;8(5):1018-26.

2. Ring AM, et al. Nature. 2013 Oct 24;502(7472):575-579.

3. Manglik A, et al. Cell. 2015 May 21;161(5):1101-1111.

4. Kahsai AW, et al. Nat Chem Biol. 2016 Sep;12(9):709-16.

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