BEN-28010 | CHK1 inhibitor | Probechem Biochemicals

Chemical Structure : BEN-28010

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BEN-28010 (BEN28010)

货号: PC-24518Not For Human Use, Lab Use Only.

BEN-28010 is a potent selective, orally bioavailable and brain-penetrant checkpoint kinase 1 (CHK1) inhibitor with IC50 of 4 nM, 450-fold selective over CHK2.

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100 mg		Get quote

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生物&药学活性

BEN-28010 is a potent selective, orally bioavailable and brain-penetrant checkpoint kinase 1 (CHK1) inhibitor with IC50 of 4 nM, 450-fold selective over CHK2.
BEN-28010 potently inhibits pCHK1 in SW620 cells with IC50 of 0.45 uM, inhibits LN-18/A172 cell viability with IC50 of 0.14/3.3 uM.
BEN-28010 also has good selectivity for CHK1 over the diverse Cerep SafetyScreen87 panel of 87 enzymes.
BEN-28010 demonstrated efficacy in several GBM CDX and PDX models as a monotherapy and in combination with ionizing radiation, including improved overall survival in an intracranially implanted GBM PDX mouse model.

物理化学性质&存储条件

分子量	374.45
分子式	C20H22N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-((1-(4-(3-(Dimethylamino)pyrrolidin-1-yl)phenyl)-1H-imidazol-4-yl) amino)pyrazine-2-carbonitrile

参考文献

1. Rawling MJ, et al. J Med Chem. 2025 Apr 24. doi: 10.1021/acs.jmedchem.5c00279.

BEN-28010 (BEN28010)

生物&药学活性

物理化学性质&存储条件

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BEN-28010 (BEN28010)

生物&药学活性

物理化学性质&存储条件

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