BE2012 | REV-ERBα antagonist | Probechem Biochemicals

Chemical Structure : BE2012

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BE2012 (BE-2012)

货号: PC-26006Not For Human Use, Lab Use Only.

BE2012 is a potent, selective first-in-class REV-ERBα/β antagonist with EC50 of 285 nM (REV-ERBα) and 0.346 nM (REV-ERBβ).

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生物&药学活性

BE2012 is a potent, selective first-in-class REV-ERBα/β antagonist with EC50 of 285 nM (REV-ERBα) and 0.346 nM (REV-ERBβ).
BE2012 has superior activity over SR8278 (REV-ERBα: EC50 = 0.446 μM).
BE2012 treatment induced key myogenic transcription factors upon acute skeletal muscle injury, similar to SR8278.

物理化学性质&存储条件

分子量	293.37
分子式	C18H19N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Amino-2-[4-(1,1-dimethylethyl)phenyl]-4(3H)-quinazolinone

参考文献

1. Maram L, et al. J Med Chem. 2026 Jan 8;69(1):439-465.

BE2012 (BE-2012)

生物&药学活性

物理化学性质&存储条件

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BE2012 (BE-2012)

生物&药学活性

物理化学性质&存储条件

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