BDM44768 | IDE inhibitor | Probechem Biochemicals

Chemical Structure : BDM44768

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BDM44768 (BDM 44768)

货号: PC-49178Not For Human Use, Lab Use Only.

BDM44768 is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE).

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生物&药学活性

BDM44768 (BDM 44768) is a potent, selective catalytic site inhibitor of insulin-degrading enzyme (IDE) with IC50 of 60 nM (hIDE).
BDM44768 displays excellent selectivity over a panel of metalloproteases (>45-fold selectivity over hNEP and hECE, no significant acitivity against hACE and hMMP-1).
BDM44768 significantly increased concentrations of Aβ1-40 in culture supernatants of human SY5Y neuroblastoma cells.
Acute treatment of mice with BDM44768 (50 mg/kg, i.p.) increases insulin signalling and surprisingly impairs glucose tolerance in an IDE-dependent manner in C57BL/6J mice.

物理化学性质&存储条件

分子量	447.470
分子式	C24H22FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-fluoro-N-((1-(4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl)-1H-1,2,3-triazol-4-yl)methyl)benzamide

参考文献

1. Deprez-Poulain R, et al. Nat Commun. 2015 Sep 23;6:8250.

BDM44768 (BDM 44768)

生物&药学活性

物理化学性质&存储条件

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BDM44768 (BDM 44768)

生物&药学活性

物理化学性质&存储条件

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