BChE inhibitor (R)-(-)-3

Chemical Structure : BChE inhibitor (R)-(-)-3

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货号: PC-24702Not For Human Use, Lab Use Only.

BChE inhibitor (R)-(-)-3 is a potent, selective butyrylcholinesterase (BChE) inhibitor with Ki of 6.6 nM, IC50 of 12 nM (hBChE), >1500-fold selective over hAChE.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

BChE inhibitor (R)-(-)-3 is a potent, selective butyrylcholinesterase (BChE) inhibitor with Ki of 6.6 nM, IC50 of 12 nM (hBChE), >1500-fold selective over hAChE.
(R)-(-)-3 (5 μM) have neuroprotective activity as tit diminished Aβ1–42-induced cell death in SH-SY5Y cells.
(R)-(-)-3 has procognitive effects in mice with scopolamine-induced AD-like symptoms, produces no cholinergic adverse effects or motor deficits and has no acute toxic effects in mice.

物理化学性质&存储条件

分子量	394.53
分子式	C23H26N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((1-Benzylpyrrolidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide

参考文献

1. Košak U, et al. J Med Chem. 2025 Jun 2. doi: 10.1021/acs.jmedchem.5c00577.