BCX1470 methanesulfonate | Factor D/C1s inhibitor | Probechem Biochemicals

Chemical Structure : BCX1470 methanesulfonate

CAS No.: 217099-44-0

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BCX1470 methanesulfonate (BCX 1470, BCX1470)

货号: PC-45882Not For Human Use, Lab Use Only.

BCX1470 methanesulfonate is a potent serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

BCX1470 methanesulfonate is a potent serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
BCX1470 methanesulfonate displays 3.4-fold and 200-fold bette than that of trypsin, respectively.
BCX1470 methanesulfonate inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively).
BCX1470 methanesulfonate blocks the reverse passive Arthus (RPA) reaction in rats.

物理化学性质&存储条件

分子量	398.4771
分子式	C15H14N2O5S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester, methanesulfonate (1:1)

参考文献

1. Szalai AJ, et al. J Immunol. 2000 Jan 1;164(1):463-8.

2. Babu, Y. S, et al. Patent No. WO 98/55471.

BCX1470 methanesulfonate (BCX 1470, BCX1470)

生物&药学活性

物理化学性质&存储条件

参考文献

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BCX1470 methanesulfonate (BCX 1470, BCX1470)

生物&药学活性

物理化学性质&存储条件

参考文献

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