BCX-3607 | TF/FVIIa inhibitor | Probechem Biochemicals

Chemical Structure : BCX-3607

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BCX-3607 (BCX3607)

货号: PC-24685Not For Human Use, Lab Use Only.

BCX-3607 is a potent, selective and orally active tissue factor/factor VIIa (TF-FVIIa) inhibitor with IC50 of 4 nM.

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生物&药学活性

BCX-3607 is a potent, selective and orally active tissue factor/factor VIIa (TF-FVIIa) inhibitor with IC50 of 4 nM.
BCX-3607 is selective over other similar serine proteases including trypsin, thrombin, Factor Xa, and others.
BCX-3607 blocks coagulation in the PT assay with a value of 6.2 μM (concentration required to double the baseline clotting time) while having little effect on the activated partial thromboplastin time.
BCX-3607 reduces wet thrombus weight in a dose-dependent manner in rat model of venous thrombosis.
BCX-3607 decreases the murine IL-6 level inflammatory response to endotoxin in mouse model of endotoxemia.
BCX-3607 (3-30 uM) blocks the FVIIa-mediated induction of IL-8 in HaCaT keratinocytes, reduces IL-6 and IL-8 levels generated by TF/FVIIa-stimulated HUVEC cells.

物理化学性质&存储条件

分子量	471.56
分子式	C27H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-(((5-carbamimidoylpyridin-2-yl)amino)methyl)-4-(isobutylcarbamoyl)-4'-vinyl-[1,1'-biphenyl]-2-carboxylic acid

参考文献

1. Arnold CS, et al. Thromb Res. 2006;117(3):343-9.

BCX-3607 (BCX3607)

生物&药学活性

物理化学性质&存储条件

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BCX-3607 (BCX3607)

生物&药学活性

物理化学性质&存储条件

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