BCT1028 | BLVRB inhibitor | Probechem Biochemicals

Chemical Structure : BCT1028

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BCT1028 (BCT-1028)

货号: PC-24394Not For Human Use, Lab Use Only.

BCT1028 is a potent, selective small molecule Biliverdin IXβ reductase (BLVRB) inhibitor with IC50 of 195 nM (50 uM BLVRB substrate DCPIP).

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生物&药学活性

BCT1028 is a potent, selective small molecule Biliverdin IXβ reductase (BLVRB) inhibitor with IC50 of 195 nM (50 uM BLVRB substrate DCPIP).
BCT1028 exhibits high selectivity against a 44-member pharmacologic in vitro target subset.
BCT1028 promotes megakaryocyte speciation in biphenotypic (erythro/megakaryocyte) cellular models and synergizes with TPO-dependent megakaryocyte formation in hematopoietic stem cells.
BCT1028 expands platelet recovery in stress thrombopoietic models with no adverse effects in mice.
Biliverdin IXβ reductase (BLVRB) is an NADPH-dependent enzyme previously implicated in a redox-regulated mechanism of thrombopoiesis distinct from the thrombopoietin (TPO)/c-MPL axis.

物理化学性质&存储条件

分子量	354.81
分子式	C18H11ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(7-(2-chlorophenyl)imidazo[5,1-b]thiazol-5-yl)benzoic acid

参考文献

1. Nesbitt NM, et al. Nat Commun. 2025 Apr 11;16(1):3480.

BCT1028 (BCT-1028)

生物&药学活性

物理化学性质&存储条件

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BCT1028 (BCT-1028)

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物理化学性质&存储条件

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