BCL6 PROTAC A19

Chemical Structure : BCL6 PROTAC A19

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货号: PC-25719Not For Human Use, Lab Use Only.

BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells.

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100 mg		Get quote

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生物&药学活性

BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells.
A19 has DC50 = 0.096 ± 0.0044 nM and Dmax ≥ 99% in the HT cell line.
A19 effectively reduces BCL6 protein levels in a concentration- and time-dependent fashion in OCI-LY1 cells.
A19 functions as a bifunctional molecule, simultaneously interacting with both BCL6 and CRBN.
A19 (50 mg/kg, p.o.) suppresses the growth of tumorin the OCI-LY1 tumor mouse model.

物理化学性质&存储条件

分子量	922.44
分子式	C46H52ClN11O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((6-((5-Chloro-2-(4-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidine-1-carbonyl)piperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide

参考文献

1. Yu X, et al. J Med Chem. 2025 Oct 9;68(19):20180-20206.

BCL6 PROTAC A19

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物理化学性质&存储条件

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BCL6 PROTAC A19

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