BCL6/GSPT1 degrader A5

Chemical Structure : BCL6/GSPT1 degrader A5

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货号: PC-28733Not For Human Use, Lab Use Only.

BCL6/GSPT1 degrader A5 is an effective, dual BCL6/GSPT1 degrader with DC50 of 0.48 nM (BCL6) in Farage cells, demonstrates excellent antiproliferative effects across multiple lymphoma cell lines (Farage cells, IC50=0.413 uM), induces DNA damage, cell cycle arrest and apoptosis.

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100 mg		Get quote

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生物&药学活性

BCL6/GSPT1 degrader A5 is an effective, dual BCL6/GSPT1 degrader with DC50 of 0.48 nM (BCL6) in Farage cells, demonstrates excellent antiproliferative effects across multiple lymphoma cell lines (Farage cells, IC50=0.413 uM), induces DNA damage, cell cycle arrest and apoptosis.

物理化学性质&存储条件

分子量	1005.47
分子式	C47H57ClN10O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinecarboxamide, 1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-N-[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]-

参考文献

1. Rong Hu, et al. Eur J Med Chem. 2026 Mar 5:305:118567.