BB07CA902

Chemical Structure : BB07CA902

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货号: PC-25852Not For Human Use, Lab Use Only.

BB07CA902 is a potent, specific, covalent inhibitor of interferon-stimulated gene 15 (ISG15) protease murine USP18 (mUSP18) with IC50 of 35 nM, effectively increases ISGylation levels in cells by inhibiting mUSP18 activity.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BB07CA902 is a potent, specific, covalent inhibitor of interferon-stimulated gene 15 (ISG15) protease murine USP18 (mUSP18) with IC50 of 35 nM, effectively increases ISGylation levels in cells by inhibiting mUSP18 activity.
BB07CA902 shows full mUSP18 specificity amongst a panel of 41 DUBs.
BB07CA902 covalently inhibits mUSP18 with an enzyme inactivation rate (kinact) over inhibition constant (Ki) ratio (kinact/Ki) of 4646 M−1s−1.
BB07CA902 is less potent toward human USP18 with IC50 of 1.2 uM.
BB07CA902 significantly elevated cellular ISGylation in a dose-dependent manner, and a maximum accumulation of ISGylation reached 10 µM.
BB07CA902 does not inhibit human USP18 in cells.
BB07CA902 inhibits in-cell mUSP18/ISG15 interaction in a dose-dependent manner with IC50 of 2.0 uM, does not inhibit the interactions of hUSP18 with ISG15 and STAT2.

物理化学性质&存储条件

分子量	311.43
分子式	C19H25N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3aR,5s,6aS)-2-cyanooctahydrocyclopenta[c]pyrrol-5-yl)-4-isopropyl-3-methylbenzamide

参考文献

1. Kooij R, et al. Angew Chem Int Ed Engl. 2025 Oct 7:e202510941.

BB07CA902

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BB07CA902

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