BAY2416964 | AHR antagonist | Probechem Biochemicals

Chemical Structure : BAY2416964

CAS No.: 2242464-44-2

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BAY2416964 (BAY 2416964, BAY-2416964)

货号: PC-38065Not For Human Use, Lab Use Only.

BAY2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with IC50 of 341 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

BAY2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with IC50 of 341 nM.

BAY 2416964 potently and selectively inhibited AhR activation induced by either exogenous or endogenous AhR ligands.

BAY 2416964 restored immune cell function in human and mouse cells, and furthermore enhanced antigen-specific cytotoxic T cell responses and killing of tumor spheroids.

BAY 2416964 induced a proinflammatory tumor microenvironment, and demonstrated antitumor efficacy in a syngeneic cancer model in mice.

物理化学性质&存储条件

分子量	387.824
分子式	C18H18ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

参考文献

1. Patent WO2018146010A1, example 192.

2, Li Wen, et al. Cell Death Dis. 2023 Jan 12;14(1):18.

BAY2416964 (BAY 2416964, BAY-2416964)

生物&药学活性

物理化学性质&存储条件

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BAY2416964 (BAY 2416964, BAY-2416964)

生物&药学活性

物理化学性质&存储条件

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