BAY-069 (BAY069)

Chemical Structure : BAY-069

CAS No.: 2639638-66-5

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货号: PC-49389Not For Human Use, Lab Use Only.

BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.

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5 mg	￥3580	In stock
10 mg	￥5480	In stock
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生物&药学活性

BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.
BAY-069 is highly selective for BCAT1/2, and shows no activity against aspartate transaminases (GOT1 and GOT2, glutamate-oxaloacetate transaminase, IC50>50 μM), also is inactive against an protease panel (30 proteases) and kinase panel (30 kinases).
BAY-069 increases cellular branched-chain amino acid (BCAA) in tumor cell lines (U-87 MG and MDA-MB-231) with IC50 of 358 and 874 nM, respectively.
BAY-069 does not inhibit cell proliferation of U-87 MG (high BCAT1 expression) and MDA-MB-231 (high BCAT2 expression) cells.
BAY-069 is a valuable tool to better understand the biology and pharmacology of BCAT inhibition in the field of tumor metabolism.

物理化学性质&存储条件

分子量	446.810
分子式	C22H14ClF3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chloro-3-(o-tolyloxy)naphthalen-1-yl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

参考文献

1. Judith Günther, et al. J Med Chem. 2022 Oct 19. doi: 10.1021/acs.jmedchem.2c00441.

BAY-069 (BAY069)

生物&药学活性

物理化学性质&存储条件

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BAY-069 (BAY069)

生物&药学活性

物理化学性质&存储条件

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