B591 |CAS:1498412-41-1 Probechem Biochemicals

Chemical Structure : B591

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B591 (B-591;B 591)

货号: PC-35993Not For Human Use, Lab Use Only.

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.

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生物&药学活性

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.
B591 induces a dose-dependent decrease of PIP3/PI (4,5)P2 ratio with IC50 of 1.91 uM in HCT116 cells.
B591 shows effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines.
B591 exhibited more potency in suppressing cancer stem cells (CSCs) survival and inducing CSCs apoptosis, and presence of B591 effectively eliminated paclitaxel-enriched CSCs.
B591 preferentially decreases CSCs levels in mouse xenograft model of human breast cancer.

物理化学性质&存储条件

分子量	528.288
分子式	C25H24Br2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-bromobenzyl)-1-((2,3-dihydrobenzofuran-5-yl)methyl)-5,6-dimethyl-1H-benzo[d]imidazol-3-ium bromide

参考文献

1. Zhou H, et al. Oncogene. 2019 Jan 11. doi: 10.1038/s41388-018-0674-5.

B591 (B-591;B 591)

生物&药学活性

物理化学性质&存储条件

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B591 (B-591;B 591)

生物&药学活性

物理化学性质&存储条件

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