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首页-小分子抑制剂&激动剂-Others-Other Targets-B1486
B1486

Chemical Structure : B1486

CAS No.: 441742-93-4

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B1486 (B-1486)

货号: PC-28165Not For Human Use, Lab Use Only.

B1486 is a highly potent, specific VprBP inhibitor with IC50 of 3.8 nM, inhibits VprBP-driven osteoclastogenesis and H2AT120p.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

B1486 is a highly potent, specific VprBP inhibitor with IC50 of 3.8 nM, inhibits VprBP-driven osteoclastogenesis and H2AT120p.
B1486 dose-dependently generates abortive OCP cell differentiation with a full inhibitory activity at low nanomolar concentrations.
B1486 inhibits RANKL-induced osteoclast differentiation by attenuating VprBP-mediated H2AT120p and re-activating anti-osteoclastogenic genes.
B1486 attenuates bone resortion in zebrafish.
B1486 interferes with bone destruction in mice.

物理化学性质&存储条件

分子量 361.47
分子式 C20H19N5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-3-carboxaldehyde, 2-methyl-, 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone

参考文献

1. Kim S, et al. J Biol Chem. 2026 Sep 8:113524.

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