Avoralstat | Plasma kallikrein inhibitor, TMPRSS2 inhibitor

Chemical Structure : Avoralstat

CAS No.: 918407-35-9

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Avoralstat (BCX4161, BCX-4161)

货号: PC-25823Not For Human Use, Lab Use Only.

Avoralstat (BCX4161) is a potent and orally active plasma kallikrein inhibitor, also is a potent, selective Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=2.73 nM).

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Avoralstat (BCX4161) is a potent and orally active plasma kallikrein inhibitor, also is a potent, selective Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=2.73 nM).
Avoralstat is 18-fold more selective toward TMPRSS2 than other S1 proteases.
Avoralstat inhibits viral entry directed by SARS-CoV-2 spike proteins.
Avoralstat inhibits SARS-CoV-2 pseudovirus entry with EC50 of 2.8 uM.
Avoralstat (30 mg/kg i.p. injection) reduces SARS-CoV-2 infection in mice.

物理化学性质&存储条件

分子量	513.55
分子式	C28H27N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinic acid

参考文献

1. Riedl MA, et al. Allergy. 2018 Sep;73(9):1871-1880.

2. Sun YJ, et al. J Clin Invest. 2021 May 17;131(10):e147973.

3. Zhang J, et al. Med Chem. 2006 Nov;2(6):545-53.

Avoralstat (BCX4161, BCX-4161)

生物&药学活性

物理化学性质&存储条件

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Avoralstat (BCX4161, BCX-4161)

生物&药学活性

物理化学性质&存储条件

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