Autophagy inhibitor 5j

Chemical Structure : Autophagy inhibitor 5j

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货号: PC-25554Not For Human Use, Lab Use Only.

Autophagy inhibitor 5j is a potent late-stage autophagy inhibitor, trigger an ER stress response and interfere with cathepsin D maturation, potentially contributing to altered lysosomal trafficking.

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100 mg		Get quote

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生物&药学活性

Autophagy inhibitor 5j is a potent late-stage autophagy inhibitor, trigger an ER stress response and interfere with cathepsin D maturation, potentially contributing to altered lysosomal trafficking.
Autophagy inhibitor 5j induces strong accumulation of RFP-GFP-LC3 puncta as well as LC3-II, GABARAP-II and SQSTM1 protein levels, resembling the effects obtained with the well-known late-stage autophagy inhibitor Bafilomycin A1.
Autophagy inhibitor 5j (10 uM) inhibits the autophagic flux at a late-stage in RFP-GFP-LC3 HeLa cells and LNCaP cells.
Autophagy inhibitor 5j stimulates the cholesterol biosynthesis pathway, dysregulates lipid metabolism, and induces ER stress and accumulation of pro-cathepsin D。

物理化学性质&存储条件

分子量	390.50
分子式	C25H27FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-((dimethylamino)methyl)benzyl)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamide

参考文献

1. Lallier M, et al. Autophagy Rep. 2025 Aug 7;4(1):2541597.