Autophagy activator AA-20

Chemical Structure : Autophagy activator AA-20

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货号: PC-25244Not For Human Use, Lab Use Only.

Autophagy activator AA-20 is a promising small-molecule autophagy enhancer/ activator, enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

Autophagy activator AA-20 is a promising small-molecule autophagy enhancer/ activator, enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.
AA-20 reduces polyglutamine aggregation in an autophagy-dependent manner in both human cells and C. elegans, where it also promotes fitness.
AA-20 extends lifespan in WT C. elegans, but not in autophagy-deficient mutants.
AA-20 acts, at least in part, through a mechanism involving the transcription factor EB, but without inhibiting the protein kinase mammalian target of rapamycin complex 1.

物理化学性质&存储条件

分子量	532.64
分子式	C26H24N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(6-ethoxybenzo[d]thiazol-2-yl)thio]-N2,N4-bis(4-methoxyphenyl)-1,3,5-triazine-2,4 diamine

参考文献

1. Tan EP, et al. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2423455122.