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首页-小分子抑制剂&激动剂-Autophagy-Autogramin-2
Autogramin-2

Chemical Structure : Autogramin-2

CAS No.: 2375541-45-8

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Autogramin-2 (Autogramin 2)

货号: PC-24731Not For Human Use, Lab Use Only.

Autogramin-2 is a small molecule autophagy inhibitor with IC50 of 0.27 uM (amino acid starvation), specifically binds to the StART domain of GRAM domain containing 1A (GRAMD1A, Aster-A) and also specifically inhibits the cholesterol-transfer activity of GRAMD1A.

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5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Autogramin-2 is a small molecule autophagy inhibitor with IC50 of 0.27 uM (amino acid starvation), specifically binds to the StART domain of GRAM domain containing 1A (GRAMD1A, Aster-A) and also specifically inhibits the cholesterol-transfer activity of GRAMD1A.
Autogramin-2 blocks cholesterol accumulation at autophagosomes and lysosomes in response to starvation in the presence of chloroquine.
Autogramin-2 does not compete with binding of 22-NBD-cholesterol to GRAMD1B (Aster-B) or GRAMD1C (Aster-C).

物理化学性质&存储条件

分子量 417.52
分子式 C21H27N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-Butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

参考文献

1. Yao-Wen Wu, et al. Autophagy. 2019 Dec;15(12):2167-2168.

2. Laraia L, et al. Nat Chem Biol. 2019 Jul;15(7):710-720.

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