Aurantiamide

Chemical Structure : Aurantiamide

CAS No.: 58115-31-4

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货号: PC-24417Not For Human Use, Lab Use Only.

Aurantiamide is a potent, non-covalent, orally active, BBB-permeable antagonist of gastrin-releasing peptide receptor (GRPR), shows anti-inflammatory and neuroprotective effects.

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生物&药学活性

Aurantiamide is a potent, non-covalent, orally active, BBB-permeable antagonist of gastrin-releasing peptide receptor (GRPR), shows anti-inflammatory and neuroprotective effects.
Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways.
Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models.

物理化学性质&存储条件

分子量	402.49
分子式	C25H26N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-1-(((S)-1-Hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

参考文献

1. He RB, et al. Int Immunopharmacol. 2024 Sep 30;139:112745.

Aurantiamide

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Aurantiamide

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