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首页-小分子抑制剂&激动剂-Others-Other Targets-Auranofin
Auranofin

Chemical Structure : Auranofin

CAS No.: 34031-32-8

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Auranofin (SKF-39162, SKF39162)

货号: PC-20604Not For Human Use, Lab Use Only.

Auranofin (SKF39162) is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer.

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10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Auranofin is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer.
Auranofin efficiently inhibits both full-length TrxR1 and TrxR2 and truncated TrxR2.
Auranofin binds to the UBA1's ubiquitin fold domain and conjugates to Cys1039 residue.
Auranofin enhances UBA1 interactions with at least 20 different E2 ubiquitin-conjugating enzymes, facilitating ubiquitin charging to E2 and increasing the activities of seven representative E3s in vitro.
Auranofin promotes ubiquitination and degradation of misfolded ER proteins during ER-associated degradation in cells at low nanomolar concentrations.

物理化学性质&存储条件

分子量 678.49
分子式 C20H34AuO9PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold

参考文献

1. Cañas A, et al. Breast Cancer Res. 2012 Dec 5;14(6):R153.
2. Dai B, et al. Cancer Res. 2013 Sep 1;73(17):5532-43.
3. Yan W, et al. Nat Commun. 2023 Aug 9;14(1):4798.

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