Atinvicitinib

Chemical Structure : Atinvicitinib

CAS No.: 2169273-59-8

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货号: PC-73400Not For Human Use, Lab Use Only.

Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis.

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生物&药学活性

Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis.

物理化学性质&存储条件

分子量	360.34
分子式	C16H17FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-4-carboxamide, 1-[(3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridinyl)amino]-

参考文献

1. Tony Siu, et al. J Med Chem. 2017 Dec 14;60(23):9676-9690.

Atinvicitinib

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Atinvicitinib

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