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首页-抗体和重组蛋白-Biosimilar Antibody-Atibuclimab
Atibuclimab

Chemical Structure : Atibuclimab

CAS No.: 2417175-94-9

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Atibuclimab (Anti-human CD14 mAb, human IgG4-Kappa; IC14)

货号: PC-Ab1060Not For Human Use, Lab Use Only.

Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia..

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5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia.

物理化学性质&存储条件

分子量
分子式 Human IgG4-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Atibuclimab; IC14; anti CD14; soluble CD14 antibody; antigen CD14; LPS R; Cluster of differentiation 14

参考文献

1. 1, Reinhart K, et al. Crit Care Med. 2004 May;32(5):1100-8. 2, Verbon A, et al. J Infect Dis. 2003 Jan 1;187(1):55-61. 3, Genth-Zotz S, et al. Eur J Heart Fail. 2006 Jun;8(4):366-72. 4, Spek CA, et al. J Clin Immunol. 2003 Mar;23(2):132-40. 5, Marongiu L, et al. Sci Signal. 2021 Mar 30;14(676):eaaz2120.

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